Variant

Variant ID Consequence Effect Gene AC AN AF NS NHOM maxEAF
10-5238779-C-T c.-48-4C>T splice_region AKR1C4 2 82512 2.42389E-5 41256 0 NA
10-5238781-A-C c.-48-2A>C splice_acceptor AKR1C4 3 82568 3.63337E-5 41284 0 3.98956E-6
10-5238849-C-A p.Arg7Ser missense AKR1C4 1 83140 1.20279E-5 41570 0 NA
10-5238849-C-T p.Arg7Cys missense AKR1C4 1 83140 1.20279E-5 41570 0 0.00100705
10-5238850-G-A p.Arg7His missense AKR1C4 1 83148 1.20267E-5 41574 0 1.59205E-4
10-5238866-T-C p.Asp12Asp synonymous AKR1C4 1 83140 1.20279E-5 41570 0 3.1839E-5
10-5238872-C-G p.His14Gln missense AKR1C4 9 83120 1.08277E-4 41560 0 4.44862E-4
10-5238872-C-T p.His14His synonymous AKR1C4 1 83120 1.20308E-5 41560 0 NA
10-5238875-C-T p.Phe15Phe synonymous AKR1C4 3 83124 3.60907E-5 41562 0 8.23818E-6
10-5238878-G-A p.Met16Ile missense AKR1C4 10 83120 1.20308E-4 41560 0 1.27527E-4
10-5238881-C-T p.Pro17Pro synonymous AKR1C4 2 83104 2.40662E-5 41552 0 3.18898E-5
10-5238882-G-T p.Val18Leu missense AKR1C4 3 83092 3.61046E-5 41546 0 3.18837E-5
10-5238882-G-A p.Val18Ile missense AKR1C4 3 83092 3.61046E-5 41546 0 3.18837E-5
10-5238885-T-C n.808T>C splice_region AKR1C4 3 83074 3.61124E-5 41537 0 1.64756E-5
10-5238912-G-T p.Glu28* stop_gained AKR1C4 1 82958 1.20543E-5 41479 0 NA
10-5238922-T-G c.84+8T>G splice_region AKR1C4 1 82848 1.20703E-5 41424 0 NA
10-5242149-G-A p.Pro30Pro synonymous AKR1C4 2 83136 2.4057E-5 41568 0 4.21088E-5
10-5242160-C-G p.Ala34Gly missense AKR1C4 1 83196 1.20198E-5 41598 0 2.50509E-5
10-5242163-T-G p.Val35Gly missense AKR1C4 1 83202 1.20189E-5 41601 0 NA
10-5242164-A-G p.Val35Val synonymous AKR1C4 16549 82556 0.200458 41278 1652 0.205452
10-5242168-G-A p.Val37Ile missense AKR1C4 1 83216 1.20169E-5 41608 0 8.29077E-6
10-5242169-T-C p.Val37Ala missense AKR1C4 2 83222 2.40321E-5 41611 0 3.31516E-5
10-5242172-C-T p.Thr38Ile missense AKR1C4 2 83222 2.40321E-5 41611 0 8.27897E-5
10-5242176-A-G p.Lys39Lys synonymous AKR1C4 5 83224 6.00788E-5 41612 0 5.03525E-4
10-5242180-G-A p.Ala41Thr missense AKR1C4 1 83250 1.2012E-5 41625 0 NA
10-5242186-G-A p.Glu43Lys missense AKR1C4 6 83254 7.20686E-5 41627 0 1.48559E-4
10-5242190-C-A p.Ala44Asp missense AKR1C4 1 83256 1.20111E-5 41628 0 NA
10-5242198-C-T p.Arg47Cys missense AKR1C4 2 83244 2.40258E-5 41622 0 1.64921E-5
10-5242199-G-A p.Arg47His missense AKR1C4 2 83248 2.40246E-5 41624 0 3.1835E-5
10-5242204-A-G p.Ile49Val missense AKR1C4 1 83272 1.20088E-5 41636 0 6.3678E-5
10-5242205-T-C p.Ile49Thr missense AKR1C4 1 83280 1.20077E-5 41640 0 3.97956E-6
10-5242207-G-T p.Asp50Tyr missense AKR1C4 1 83286 1.20068E-5 41643 0 NA
10-5242207-G-A p.Asp50Asn missense AKR1C4 1 83286 1.20068E-5 41643 0 3.97956E-6
10-5242220-T-C p.Leu54Ser missense AKR1C4 1 83290 1.20062E-5 41645 0 8.24253E-6
10-5242224-CAAT-C p.Asn57del conservative_inframe_deletion AKR1C4 36 83290 4.32225E-4 41645 0 0.00114613
10-5242226-A-G p.Asn56Ser missense AKR1C4 1 83308 1.20036E-5 41654 0 1.64902E-5
10-5242231-G-A p.Glu58Lys missense AKR1C4 4 83308 4.80146E-5 41654 0 1.64851E-5
10-5242233-G-T p.Glu58Asp missense AKR1C4 2 83310 2.40067E-5 41655 1 NA
10-5242236-G-A p.Glu59Glu synonymous AKR1C4 1 83310 1.20034E-5 41655 0 NA
10-5242252-A-G p.Ile65Val missense AKR1C4 14 83324 1.68019E-4 41662 0 5.03525E-4
10-5242255-C-T p.Arg66* stop_gained AKR1C4 2 83330 2.4001E-5 41665 0 4.94772E-5
10-5242256-G-A p.Arg66Gln missense AKR1C4 1 83326 1.20011E-5 41663 0 7.95792E-6
10-5242261-A-AAGATTGC p.Gly72fs frameshift AKR1C4 1 83332 1.20002E-5 41666 0 NA
10-5242265-T-C p.Ile69Thr missense AKR1C4 13 83332 1.56002E-4 41666 0 1.15387E-4
10-5242272-T-C p.Asp71Asp synonymous AKR1C4 1 83328 1.20008E-5 41664 0 3.18329E-5
10-5242277-G-A p.Ser73Asn missense AKR1C4 3 83328 3.60023E-5 41664 0 6.36699E-5
10-5242278-T-C p.Ser73Ser synonymous AKR1C4 1 83330 1.20005E-5 41665 0 8.29641E-6
10-5242279-G-A p.Val74Met missense AKR1C4 1 83322 1.20016E-5 41661 0 NA
10-5242286-G-C p.Arg76Thr missense AKR1C4 50 83302 6.00226E-4 41651 0 6.36659E-4
10-5242286-G-A p.Arg76Lys missense AKR1C4 1 83302 1.20045E-5 41651 0 1.99291E-5
10-5242286-G-T p.Arg76Ile missense AKR1C4 1 83302 1.20045E-5 41651 0 NA
10-5242291-G-A p.Asp78Asn missense AKR1C4 1 83276 1.20083E-5 41638 0 8.33194E-6
10-5242292-A-T p.Asp78Val missense AKR1C4 1 83266 1.20097E-5 41633 0 NA
10-5242297-T-C p.Phe80Leu missense AKR1C4 1 83244 1.20129E-5 41622 0 NA
10-5242301-A-G p.Tyr81Cys missense AKR1C4 4 83222 4.80642E-5 41611 0 2.00192E-5
10-5242306-T-G p.Ser83Ala missense AKR1C4 1 83176 1.20227E-5 41588 0 NA
10-5242316-T-C c.252+5T>C splice_region AKR1C4 1 83046 1.20415E-5 41523 0 NA
10-5246335-T-G c.253-5T>G splice_region AKR1C4 11 82962 1.32591E-4 41481 0 1.59185E-4
10-5246344-G-C p.Trp86Ser missense AKR1C4 2 83022 2.409E-5 41511 0 NA
10-5246346-T-C p.Cys87Arg missense AKR1C4 2 83026 2.40888E-5 41513 0 3.98889E-6
10-5246348-C-T p.Cys87Cys synonymous AKR1C4 1 83040 1.20424E-5 41520 0 NA
10-5246358-C-G p.Gln91Glu missense AKR1C4 1 83096 1.20343E-5 41548 0 3.18552E-5
10-5246362-C-T p.Pro92Leu missense AKR1C4 1 83114 1.20317E-5 41557 0 9.55536E-5
10-5246367-A-T p.Met94Leu missense AKR1C4 1 83144 1.20273E-5 41572 0 3.18492E-5
10-5246368-T-C p.Met94Thr missense AKR1C4 3 83152 3.60785E-5 41576 0 8.75754E-5
10-5246373-C-T p.Gln96* stop_gained AKR1C4 1 83158 1.20253E-5 41579 0 8.23995E-6
10-5246376-C-G p.Pro97Ala missense AKR1C4 1 83180 1.20221E-5 41590 0 NA
10-5246377-C-T p.Pro97Leu missense AKR1C4 1 83180 1.20221E-5 41590 0 NA
10-5246384-G-A p.Leu99Leu synonymous AKR1C4 3 83180 3.60664E-5 41590 0 0.00100806
10-5246393-A-AC p.Leu103fs frameshift AKR1C4 6 83196 7.21189E-5 41598 0 3.1841E-5
10-5246396-G-GA p.Leu106fs frameshift AKR1C4 3 83210 3.60534E-5 41605 0 8.23968E-6
10-5246408-A-G p.Gln107Gln synonymous AKR1C4 1 83216 1.20169E-5 41608 0 1.59196E-5
10-5246426-C-G p.Leu113Leu synonymous AKR1C4 2 83202 2.40379E-5 41601 0 NA
10-5246428-A-G p.Tyr114Cys missense AKR1C4 4 83210 4.80711E-5 41605 0 7.96356E-5
10-5246436-C-A p.His117Asn missense AKR1C4 2 83184 2.40431E-5 41592 0 3.18492E-5
10-5246451-C-T p.Leu122Phe missense AKR1C4 2 83170 2.40471E-5 41585 0 NA
10-5246455-A-T p.Lys123Met missense+splice_region AKR1C4 1 83154 1.20259E-5 41577 0 3.98826E-6
10-5246457-G-A c.369+1G>A splice_donor AKR1C4 4 83146 4.81081E-5 41573 0 8.24769E-6
10-5247725-T-C p.Gly125Gly synonymous AKR1C4 1 82840 1.20715E-5 41420 0 1.99669E-5
10-5247730-C-T p.Thr127Met missense AKR1C4 11 82876 1.32728E-4 41438 0 2.22916E-4
10-5247738-C-T p.Pro130Ser missense AKR1C4 1 82954 1.20549E-5 41477 0 8.27239E-6
10-5247740-A-G p.Pro130Pro synonymous AKR1C4 2 82996 2.40975E-5 41498 0 NA
10-5247754-G-A p.Gly135Glu missense AKR1C4 945 83028 0.0113817 41514 38 0.0250987
10-5247762-A-G p.Ile138Val missense AKR1C4 1 83088 1.20354E-5 41544 0 8.26023E-6
10-5247765-T-C p.Phe139Leu missense AKR1C4 1 83096 1.20343E-5 41548 0 8.26105E-6
10-5247768-G-A p.Asp140Asn missense AKR1C4 3 83098 3.6102E-5 41549 0 8.262E-5
10-5247769-A-T p.Asp140Val missense AKR1C4 1 83096 1.20343E-5 41548 0 NA
10-5247774-G-A p.Val142Met missense AKR1C4 2 83104 2.40662E-5 41552 0 8.26296E-6
10-5247776-G-A p.Val142Val synonymous AKR1C4 9 83110 1.0829E-4 41555 0 3.1837E-5
10-5247779-T-C p.Asp143Asp synonymous AKR1C4 3 83120 3.60924E-5 41560 0 8.26446E-6
10-5247784-C-G p.Ser145Cys missense AKR1C4 10475 82930 0.126311 41465 724 0.137665
10-5247785-T-C p.Ser145Ser synonymous AKR1C4 1 83114 1.20317E-5 41557 0 NA
10-5247794-G-C p.Trp148Cys missense AKR1C4 2 83114 2.40633E-5 41557 0 1.65848E-5
10-5247802-G-A c.447+5G>A splice_region AKR1C4 1 83098 1.2034E-5 41549 0 NA
10-5248230-C-A c.448-8C>A splice_region AKR1C4 3 82820 3.62231E-5 41410 0 1.64891E-5
10-5248233-C-T c.448-5C>T splice_region AKR1C4 2 82878 2.41319E-5 41439 0 0.0025
10-5248234-C-A c.448-4C>A splice_region AKR1C4 2 82884 2.41301E-5 41442 0 NA
10-5248240-C-T p.Val150Val splice_region+synonymous AKR1C4 1 83040 1.20424E-5 41520 0 8.24226E-6
10-5248244-G-A p.Glu152Lys missense AKR1C4 1 83094 1.20346E-5 41547 0 3.9794E-6
10-5248253-A-C p.Lys155Gln missense AKR1C4 1 83200 1.20192E-5 41600 0 3.97814E-6
10-5248255-G-A p.Lys155Lys synonymous AKR1C4 1 83224 1.20158E-5 41612 0 3.18236E-5
10-5248257-A-C p.Asp156Ala missense AKR1C4 5 83234 6.00716E-5 41617 0 1.64807E-5
10-5248257-A-T p.Asp156Val missense AKR1C4 3 83234 3.6043E-5 41617 0 0.001875
10-5248258-T-C p.Asp156Asp synonymous AKR1C4 1 83244 1.20129E-5 41622 0 3.1837E-5
10-5248263-G-A p.Gly158Glu missense AKR1C4 1 83284 1.20071E-5 41642 0 NA
10-5248267-G-A p.Leu159Leu synonymous AKR1C4 1 83292 1.2006E-5 41646 0 2.47198E-5
10-5248278-T-G p.Ile163Ser missense AKR1C4 2 83346 2.39964E-5 41673 0 NA
10-5248280-G-A p.Gly164Arg missense AKR1C4 22 83362 2.63909E-4 41681 1 1.07392E-4
10-5248283-G-A p.Val165Met missense AKR1C4 2 83366 2.39906E-5 41683 0 3.97722E-6
10-5248285-G-A p.Val165Val synonymous AKR1C4 2 83370 2.39894E-5 41685 0 4.773E-5
10-5248298-T-C p.Cys170Arg missense AKR1C4 1 83390 1.19918E-5 41695 0 NA
10-5248299-G-T p.Cys170Phe missense AKR1C4 1 83386 1.19924E-5 41693 0 NA
10-5248299-G-A p.Cys170Tyr missense AKR1C4 1 83388 1.19921E-5 41694 0 3.97738E-6
10-5248327-G-A p.Lys179Lys synonymous AKR1C4 1 83378 1.19936E-5 41689 0 3.29603E-5
10-5248332-G-T p.Gly181Val missense AKR1C4 9 83386 1.07932E-4 41693 0 7.49823E-4
10-5248334-C-G p.Leu182Val missense AKR1C4 21 83374 2.51877E-4 41687 0 7.00592E-4
10-5248339-G-A p.Lys183Lys synonymous AKR1C4 1 83362 1.19959E-5 41681 0 1.1935E-5
10-5248347-C-T p.Pro186Leu missense AKR1C4 1 83362 1.19959E-5 41681 0 NA
10-5248349-G-A p.Val187Ile missense AKR1C4 2 83358 2.39929E-5 41679 0 NA
10-5254574-T-TA c.571-5_571-4insA splice_region AKR1C4 2 82100 2.43605E-5 41050 0 4.16778E-5
10-5254592-C-G p.Pro195Arg missense AKR1C4 1 82476 1.21247E-5 41238 0 NA
10-5254597-C-T p.Leu197Phe missense AKR1C4 1 82554 1.21133E-5 41277 0 8.26446E-6
10-5254599-C-CA p.Asn198fs frameshift AKR1C4 1 82608 1.21054E-5 41304 0 NA
10-5254603-C-A p.Gln199Lys missense AKR1C4 1 82682 1.20945E-5 41341 0 NA
10-5254624-T-G p.Cys206Gly missense AKR1C4 1 82974 1.2052E-5 41487 0 1.19389E-5
10-5254625-G-C p.Cys206Ser missense AKR1C4 1 82982 1.20508E-5 41491 0 NA
10-5254631-C-CA p.Asp210fs frameshift AKR1C4 1 82992 1.20494E-5 41496 0 NA
10-5254641-T-C p.Ile211Ile synonymous AKR1C4 2 83034 2.40865E-5 41517 0 2.78594E-5
10-5254643-T-C p.Val212Ala missense AKR1C4 3 83034 3.61298E-5 41517 0 1.59203E-5
10-5254658-G-C p.Ser217Thr missense AKR1C4 1 82998 1.20485E-5 41499 0 NA
10-5254663-C-G p.Leu219Val missense AKR1C4 1 82978 1.20514E-5 41489 0 NA
10-5254667-G-A p.Gly220Glu missense AKR1C4 1 82976 1.20517E-5 41488 0 3.1841E-5
10-5254671-CCAA-C p.Gln222del disruptive_inframe_deletion AKR1C4 5 82956 6.02729E-5 41478 0 3.30284E-5
10-5254675-C-T p.Arg223* stop_gained AKR1C4 4 82942 4.82265E-5 41471 0 2.47844E-5
10-5254675-C-A p.Arg223Arg synonymous AKR1C4 2 82942 2.41132E-5 41471 0 8.26146E-6
10-5254676-G-A p.Arg223Gln missense AKR1C4 1 82920 1.20598E-5 41460 0 7.43605E-5
10-5254678-CAT-C p.His224fs frameshift AKR1C4 4 82902 4.82497E-5 41451 0 3.30606E-5
10-5254688-G-A p.Trp227* stop_gained AKR1C4 2 82844 2.41418E-5 41422 0 8.28748E-6
10-5254689-G-A c.680+1G>A splice_donor AKR1C4 3 82830 3.62188E-5 41415 0 3.1839E-5
10-5254960-G-A p.Val228Val synonymous AKR1C4 2 83008 2.40941E-5 41504 0 NA
10-5254963-C-A p.Asp229Glu missense AKR1C4 1 83022 1.2045E-5 41511 0 3.18471E-5
10-5254967-A-G p.Asn231Asp missense AKR1C4 1 83046 1.20415E-5 41523 0 NA
10-5254970-T-C p.Ser232Pro missense AKR1C4 1 83054 1.20404E-5 41527 0 NA
10-5254974-C-T p.Pro233Leu missense AKR1C4 1 83038 1.20427E-5 41519 0 NA
10-5254975-A-AG p.Val234fs frameshift AKR1C4 1 83050 1.20409E-5 41525 0 3.9834E-6
10-5254980-T-C p.Leu235Pro missense AKR1C4 13 83060 1.56513E-4 41530 0 0.001875
10-5254985-G-C p.Glu237Gln missense AKR1C4 9 83056 1.08361E-4 41528 1 0.00100705
10-5254985-G-A p.Glu237Lys missense AKR1C4 1 83056 1.20401E-5 41528 0 NA
10-5254992-C-T p.Pro239Leu missense AKR1C4 1 83070 1.2038E-5 41535 0 NA
10-5255001-G-T p.Cys242Phe missense AKR1C4 2 83092 2.40697E-5 41546 0 NA
10-5255003-G-A p.Ala243Thr missense AKR1C4 193 83094 0.00232267 41547 3 0.0060423
10-5255009-G-A p.Ala245Thr missense AKR1C4 1 83128 1.20296E-5 41564 0 NA
10-5255011-A-G p.Ala245Ala synonymous AKR1C4 1 83134 1.20288E-5 41567 0 1.19422E-5
10-5255016-A-G p.Lys247Arg missense AKR1C4 1 83146 1.2027E-5 41573 0 NA
10-5255016-AAC-A p.His248fs frameshift AKR1C4 2 83146 2.40541E-5 41573 0 3.98032E-6
10-5255024-C-T p.Gln250* stop_gained AKR1C4 2 83132 2.40581E-5 41566 0 3.18471E-5
10-5255025-A-G p.Gln250Arg missense AKR1C4 82989 82998 0.999892 41499 41492 1.0
10-5255040-T-C p.Ile255Thr missense AKR1C4 2 83194 2.40402E-5 41597 0 6.36983E-5
10-5255041-T-G p.Ile255Met missense AKR1C4 1 83194 1.20201E-5 41597 0 NA
10-5255043-C-T p.Ala256Val missense AKR1C4 1 83180 1.20221E-5 41590 0 NA
10-5255048-C-T p.Arg258Cys missense AKR1C4 5 83186 6.01063E-5 41593 0 1.23638E-4
10-5255049-G-A p.Arg258His missense AKR1C4 1 83182 1.20218E-5 41591 0 5.17326E-5
10-5255063-C-T p.Arg263Cys missense AKR1C4 5 83216 6.00846E-5 41608 0 1.2738E-4
10-5255064-G-A p.Arg263His missense AKR1C4 16 83222 1.92257E-4 41611 0 5.03525E-4
10-5255076-T-G p.Val267Gly missense AKR1C4 1 83242 1.20132E-5 41621 0 NA
10-5255076-T-C p.Val267Ala missense AKR1C4 3 83242 3.60395E-5 41621 0 1.64807E-5
10-5255077-C-T p.Val267Val synonymous AKR1C4 1 83232 1.20146E-5 41616 0 6.36821E-5
10-5255080-G-C p.Leu268Leu synonymous AKR1C4 2 83226 2.4031E-5 41613 0 1.19351E-5
10-5255083-C-A p.Ala269Ala synonymous AKR1C4 1 83194 1.20201E-5 41597 0 NA
10-5255098-G-C p.Glu274Asp missense AKR1C4 2 83058 2.40796E-5 41529 0 NA
10-5255099-C-T p.Gln275* stop_gained AKR1C4 2 83040 2.40848E-5 41520 0 8.24294E-6
10-5255102-C-A p.Arg276Arg synonymous AKR1C4 1 82962 1.20537E-5 41481 0 6.36821E-5
10-5255102-C-T p.Arg276Trp missense AKR1C4 2 82962 2.41074E-5 41481 0 9.55231E-5
10-5255103-G-A p.Arg276Gln missense AKR1C4 7 82946 8.43923E-5 41473 0 5.03525E-4
10-5255104-G-A p.Arg276Arg synonymous AKR1C4 1 82936 1.20575E-5 41468 0 1.19385E-5
10-5255116-C-T p.Asn280Asn synonymous AKR1C4 2 82770 2.41633E-5 41385 0 NA
10-5255120-C-T p.Gln282* stop_gained AKR1C4 1 82716 1.20896E-5 41358 0 NA
10-5255127-G-T c.846+5G>T splice_region AKR1C4 1 82630 1.21021E-5 41315 0 NA
10-5258673-G-A c.847-1G>A splice_acceptor AKR1C4 1 82958 1.20543E-5 41479 0 NA
10-5258680-G-T p.Glu285* stop_gained AKR1C4 1 82996 1.20488E-5 41498 0 NA
10-5258685-C-G p.Phe286Leu missense AKR1C4 1 82990 1.20496E-5 41495 0 NA
10-5258700-GG-AT p.GluAsp291GluTyr missense AKR1C4 2 83058 2.40796E-5 41529 0 NA
10-5258722-C-T p.Leu299Leu synonymous AKR1C4 1 83084 1.2036E-5 41542 0 NA
10-5258724-A-G p.Leu299Leu synonymous AKR1C4 1 83070 1.2038E-5 41535 0 NA
10-5258736-T-C p.Tyr303Tyr synonymous AKR1C4 1 83052 1.20406E-5 41526 0 3.1839E-5
10-5258738-G-A p.Arg304Gln missense AKR1C4 2 82998 2.4097E-5 41499 0 3.1837E-5
10-5258740-T-C p.Tyr305His missense AKR1C4 2 83028 2.40883E-5 41514 0 3.18431E-5
10-5258750-T-A p.Met308Lys missense AKR1C4 12 82930 1.447E-4 41465 0 2.22859E-4
10-5258750-T-C p.Met308Thr missense AKR1C4 14 82930 1.68817E-4 41465 0 1.66372E-4
10-5258760-AG-A c.929+5delG splice_region AKR1C4 5 82796 6.03894E-5 41398 0 1.27402E-4
10-5260673-CTT-C c.930-7_930-6delTT splice_region AKR1C4 1 82672 1.2096E-5 41336 0 3.98963E-6
10-5260676-T-A c.930-5T>A splice_region AKR1C4 1 82664 1.20972E-5 41332 0 NA
10-5260677-T-C c.930-4T>C splice_region AKR1C4 1 82674 1.20957E-5 41337 0 NA
10-5260682-C-G p.Leu311Val missense+splice_region AKR1C4 10107 82214 0.122935 41107 663 0.136379
10-5260682-CT-GG p.Leu311Gly missense+splice_region AKR1C4 2 82696 2.4185E-5 41348 0 NA
10-5260683-T-G p.Leu311Arg missense+splice_region AKR1C4 1 82702 1.20916E-5 41351 0 6.37024E-5
10-5260687-G-A p.Met312Ile missense AKR1C4 1 82688 1.20937E-5 41344 0 NA
10-5260690-C-T p.Asp313Asp synonymous AKR1C4 1 82666 1.20969E-5 41333 0 3.98438E-6