Variant

Variant ID Consequence Effect Gene AC AN AF NS NHOM maxEAF
7-87563687-G-T c.-94G>T 5_prime_UTR_premature_start_codon_gain ADAM22 2 44502 4.49418E-5 22251 0 NA
7-87563736-A-T c.-45A>T 5_prime_UTR_premature_start_codon_gain ADAM22 8 58406 1.36972E-4 29203 0 2.87853E-4
7-87563771-C-T c.-10C>T 5_prime_UTR_premature_start_codon_gain ADAM22 2 65768 3.04099E-5 32884 0 3.86414E-5
7-87563788-C-T p.Ala3Val missense ADAM22 1 69076 1.44768E-5 34538 0 NA
7-87563789-G-T p.Ala3Ala synonymous ADAM22 1 69464 1.43959E-5 34732 0 4.48877E-6
7-87563794-T-G p.Val5Gly missense ADAM22 66 70406 9.3742E-4 35203 1 0.00682636
7-87563804-C-T p.Ser8Ser synonymous ADAM22 46 72052 6.38428E-4 36026 0 0.0010101
7-87563806-T-G p.Val9Gly missense ADAM22 1 72352 1.38213E-5 36176 0 NA
7-87563813-C-T p.Phe11Phe synonymous ADAM22 1 73334 1.36362E-5 36667 0 4.2289E-6
7-87563828-C-T p.Val16Val synonymous ADAM22 1 73982 1.35168E-5 36991 0 8.40075E-6
7-87563844-C-T p.Pro22Ser missense ADAM22 1 73904 1.35311E-5 36952 0 NA
7-87563845-C-T p.Pro22Leu missense ADAM22 1 73886 1.35344E-5 36943 0 5.04541E-4
7-87563851-G-C p.Arg24Pro missense ADAM22 9 73814 1.21928E-4 36907 0 9.57121E-5
7-87563852-C-T p.Arg24Arg synonymous ADAM22 3 73896 4.05976E-5 36948 0 NA
7-87563857-G-T p.Gly26Val missense ADAM22 4 73912 5.41184E-5 36956 0 4.19384E-5
7-87563863-C-T p.Ala28Val missense+splice_region ADAM22 2 73706 2.71348E-5 36853 0 NA
7-87563873-A-T c.85+8A>T splice_region ADAM22 1 73226 1.36564E-5 36613 0 NA
7-87564139-C-T c.-216C>T 5_prime_UTR_premature_start_codon_gain ADAM22 3 69828 4.29627E-5 34914 0 4.17014E-5
7-87564155-C-T c.-200C>T 5_prime_UTR_premature_start_codon_gain ADAM22 2 71006 2.81666E-5 35503 0 6.25E-4
7-87564184-G-T c.-171G>T 5_prime_UTR_premature_start_codon_gain ADAM22 1 74792 1.33704E-5 37396 0 7.22993E-6
7-87564241-C-T c.-114C>T 5_prime_UTR_premature_start_codon_gain ADAM22 2 79956 2.50138E-5 39978 0 4.31485E-6
7-87564305-C-G c.-50C>G 5_prime_UTR_premature_start_codon_gain ADAM22 1 82602 1.21062E-5 41301 0 4.01987E-6
7-87564335-C-G c.86-6C>G splice_region ADAM22 1 83000 1.20482E-5 41500 0 8.02349E-6
7-87564342-A-T p.Gly29Gly splice_region+synonymous ADAM22 1 82972 1.20523E-5 41486 0 NA
7-87564348-C-G p.Ala31Ala synonymous ADAM22 1 82932 1.20581E-5 41466 0 6.37024E-5
7-87564350-C-T p.Ser32Leu missense ADAM22 13 82944 1.56732E-4 41472 0 5.03525E-4
7-87564352-T-C c.-3T>C 5_prime_UTR_premature_start_codon_gain ADAM22 1 82916 1.20604E-5 41458 0 3.18695E-5
7-87564353-T-C p.Leu33Ser missense ADAM22 1 82904 1.20621E-5 41452 0 2.00523E-5
7-87564355-A-G p.Met1? start_lost ADAM22 1 82872 1.20668E-5 41436 0 NA
7-87564361-C-T p.Leu36Leu synonymous ADAM22 9 82768 1.08738E-4 41384 0 1.08406E-4
7-87564361-C-A p.Leu36Ile missense ADAM22 1 82768 1.2082E-5 41384 0 NA
7-87564372-G-A p.Arg39Arg synonymous ADAM22 1 82492 1.21224E-5 41246 0 NA
7-87564381-C-G p.Asn42Lys missense ADAM22 1 82154 1.21723E-5 41077 0 3.18593E-5
7-87564388-G-A p.Val45Met missense ADAM22 144 81690 0.00176276 40845 4 0.00532039
7-87564389-T-C p.Val45Ala missense ADAM22 1 81622 1.22516E-5 40811 0 NA
7-87564392-A-G p.Glu46Gly missense ADAM22 3 81448 3.68333E-5 40724 0 8.3724E-6
7-87564405-C-T p.Ile50Ile synonymous ADAM22 1 80496 1.2423E-5 40248 0 NA
7-87564418-C-T p.Leu55Phe missense ADAM22 22 79148 2.7796E-4 39574 0 0.0010903
7-87564428-GC-AT p.Arg58His missense ADAM22 2 77120 2.59336E-5 38560 0 NA
7-87564435-C-T p.Gly60Gly synonymous ADAM22 2 75686 2.6425E-5 37843 0 3.18817E-5
7-87564437-G-T p.Gly61Val missense ADAM22 1 75078 1.33195E-5 37539 0 8.59476E-6
7-87564466-G-T p.Asp71Tyr missense ADAM22 1 66532 1.50304E-5 33266 0 2.91574E-5
7-87564496-C-G p.Pro81Ala missense ADAM22 7 55958 1.25094E-4 27979 0 5.05051E-4
7-87564496-CC-GG p.Pro81Gly missense ADAM22 10 55956 1.78712E-4 27978 0 NA
7-87564497-C-G p.Pro81Arg missense ADAM22 24999 49110 0.509041 24555 6311 0.632004
7-87564497-C-T p.Pro81Leu missense ADAM22 1 55858 1.79025E-5 27929 0 4.53498E-6
7-87593954-G-A p.Gln84Gln synonymous ADAM22 1 52108 1.91909E-5 26054 0 NA
7-87593985-A-G p.Ile95Val missense ADAM22 2 52420 3.81534E-5 26210 0 NA
7-87593990-C-T p.Tyr96Tyr synonymous ADAM22 1 52376 1.90927E-5 26188 0 8.94534E-6
7-87593991-CAGAT-C p.Gln97fs frameshift ADAM22 84 52392 0.0016033 26196 1 0.00284145
7-87594005-G-A c.297+6G>A splice_region ADAM22 2 47832 4.1813E-5 23916 0 NA
7-87607698-G-A p.Thr98Thr synonymous ADAM22 4 83248 4.80492E-5 41624 0 2.81012E-5
7-87607705-A-G p.Ile101Val missense ADAM22 9 83246 1.08113E-4 41623 0 4.01313E-6
7-87607708-C-T p.Leu102Phe missense ADAM22 1 83258 1.20109E-5 41629 0 NA
7-87607714-G-A p.Val104Ile missense ADAM22 1 83244 1.20129E-5 41622 0 NA
7-87607716-C-T p.Val104Val synonymous ADAM22 5 83238 6.00687E-5 41619 0 3.18634E-5
7-87607717-G-A p.Val105Met missense ADAM22 2 83222 2.40321E-5 41611 0 6.25E-4
7-87704937-G-A c.324-4G>A splice_region ADAM22 1 82868 1.20674E-5 41434 0 4.01378E-6
7-87704938-C-T c.324-3C>T splice_region ADAM22 1 82860 1.20685E-5 41430 0 NA
7-87704948-C-T p.Leu111Leu synonymous ADAM22 1 82954 1.20549E-5 41477 0 3.18573E-5
7-87704964-T-C p.Ile116Thr missense ADAM22 7 83032 8.43048E-5 41516 0 1.27413E-4
7-87704972-C-T p.His119Tyr missense ADAM22 292 83042 0.00351629 41521 4 0.00554241
7-87704976-T-C p.Ile120Thr missense ADAM22 1 83058 1.20398E-5 41529 0 1.65763E-5
7-87704984-G-A p.Gly123Arg missense ADAM22 2 83034 2.40865E-5 41517 0 8.28816E-6
7-87704999-G-A p.Glu128Lys missense ADAM22 1361 82972 0.0164031 41486 16 0.0172029
7-87737487-T-A c.391-4T>A splice_region ADAM22 1 82656 1.20983E-5 41328 0 8.40845E-6
7-87737511-C-T p.Tyr137Tyr synonymous ADAM22 3 82868 3.62022E-5 41434 0 4.01852E-6
7-87737525-G-A p.Arg142Gln missense ADAM22 5 82920 6.02991E-5 41460 0 3.18573E-5
7-87737526-A-G p.Arg142Arg synonymous ADAM22 6 82930 7.23502E-5 41465 0 7.63236E-5
7-87737531-A-G p.Asn144Ser missense ADAM22 1 82928 1.20587E-5 41464 0 3.18613E-5
7-87737533-C-T p.Pro145Ser missense ADAM22 2 82930 2.41167E-5 41465 0 1.27445E-4
7-87737543-T-C p.Phe148Ser missense ADAM22 5 82896 6.03165E-5 41448 0 4.99276E-5
7-87737546-T-C p.Val149Ala missense ADAM22 1 82876 1.20662E-5 41438 0 NA
7-87737557-A-C p.Thr153Pro missense ADAM22 3 82824 3.62214E-5 41412 0 8.04253E-6
7-87737565-C-T p.His155His synonymous ADAM22 7 82718 8.46249E-5 41359 0 6.25E-4
7-87737581-T-C c.473+8T>C splice_region ADAM22 2 82486 2.42465E-5 41243 0 NA
7-87743891-G-A c.474-8G>A splice_region ADAM22 4 83028 4.81765E-5 41514 0 4.01381E-5
7-87743910-A-G p.Tyr162Cys missense ADAM22 1 83144 1.20273E-5 41572 0 2.00502E-5
7-87743914-C-T p.Asp163Asp synonymous ADAM22 5 83164 6.01222E-5 41582 0 9.55657E-5
7-87743915-G-A p.Gly164Arg missense ADAM22 18 83154 2.16466E-4 41577 0 1.59286E-4
7-87743915-G-T p.Gly164Trp missense ADAM22 3 83154 3.60776E-5 41577 0 3.18573E-5
7-87743920-C-T p.Asn165Asn synonymous ADAM22 1 83158 1.20253E-5 41579 0 NA
7-87743921-C-A p.His166Asn missense ADAM22 1 83164 1.20244E-5 41582 0 1.60406E-5
7-87743928-A-T p.Tyr168Phe missense ADAM22 5 83152 6.01308E-5 41576 0 1.20294E-5
7-87743929-T-C p.Tyr168Tyr synonymous ADAM22 3 83154 3.60776E-5 41577 0 8.28858E-6
7-87743941-A-G p.Pro172Pro synonymous ADAM22 3 83150 3.60794E-5 41575 0 2.40684E-5
7-87743945-GAA-G p.Asn175fs frameshift ADAM22 1 83154 1.20259E-5 41577 0 3.18471E-5
7-87743948-A-G p.Asn175Asp missense ADAM22 1 83148 1.20267E-5 41574 0 NA
7-87743949-A-C p.Asn175Thr missense ADAM22 1 83150 1.20265E-5 41575 0 3.18512E-5
7-87743950-TGA-T p.Asp176fs frameshift ADAM22 1 83148 1.20267E-5 41574 0 3.18512E-5
7-87743961-A-C p.Gln179Pro missense+splice_region ADAM22 1 83142 1.20276E-5 41571 0 4.01155E-6
7-87746052-C-T c.538-8C>T splice_region ADAM22 3 82312 3.64467E-5 41156 0 NA
7-87746084-T-A p.Tyr188Asn missense ADAM22 2 82514 2.42383E-5 41257 0 NA
7-87746101-T-G p.Phe193Leu missense ADAM22 1 82478 1.21244E-5 41239 0 NA
7-87746103-A-C p.Glu194Ala missense ADAM22 83 82462 0.00100652 41231 0 0.00470154
7-87746111-T-C p.Leu197Leu synonymous ADAM22 10 82442 1.21297E-4 41221 0 4.77525E-4
7-87746116-T-G p.Asp198Glu missense ADAM22 1 82392 1.21371E-5 41196 0 4.02431E-6
7-87746128-T-C p.Ser202Ser splice_region+synonymous ADAM22 1 82300 1.21507E-5 41150 0 NA
7-87746133-T-C c.607+4T>C splice_region ADAM22 2 82212 2.43273E-5 41106 0 NA
7-87754911-G-A p.Gln205Gln synonymous ADAM22 1 82676 1.20954E-5 41338 0 NA
7-87754912-C-A p.Gln206Lys missense ADAM22 2 82688 2.41873E-5 41344 0 8.57287E-6
7-87754915-G-A p.Val207Ile missense ADAM22 5332 82484 0.0646428 41242 215 0.0946626
7-87754954-C-G p.Pro220Ala missense ADAM22 2 82756 2.41674E-5 41378 0 NA
7-87754955-C-G p.Pro220Arg missense ADAM22 74 82754 8.94217E-4 41377 0 0.00239049
7-87754969-C-T p.Arg225Trp missense ADAM22 3 82738 3.6259E-5 41369 0 9.56877E-5
7-87754974-G-A p.Gln226Gln splice_region+synonymous ADAM22 102 82716 0.00123314 41358 1 0.00302914
7-87754980-T-A c.678+6T>A splice_region ADAM22 1 82692 1.20931E-5 41346 0 6.37714E-5
7-87757921-G-A p.Arg228His missense ADAM22 1 83012 1.20465E-5 41506 0 5.03525E-4
7-87757923-C-G p.Arg229Gly missense ADAM22 4 83020 4.81812E-5 41510 0 4.15069E-5
7-87757924-G-A p.Arg229Gln missense ADAM22 2 83026 2.40888E-5 41513 0 3.32033E-5
7-87757932-C-T p.Arg232Cys missense ADAM22 12 83050 1.44491E-4 41525 0 6.25E-4
7-87757933-G-A p.Arg232His missense ADAM22 1 83046 1.20415E-5 41523 0 8.29903E-6
7-87757939-T-TAGA p.Glu237dup conservative_inframe_insertion ADAM22 34 83068 4.09303E-4 41534 0 4.14224E-4
7-87757946-A-G p.Glu236Glu synonymous ADAM22 1 83070 1.2038E-5 41535 0 NA
7-87757950-A-G p.Thr238Ala missense ADAM22 1 83094 1.20346E-5 41547 0 NA
7-87757952-C-T p.Thr238Thr synonymous ADAM22 13 83086 1.56464E-4 41543 0 1.07875E-4
7-87757955-A-G p.Lys239Lys synonymous ADAM22 2 83088 2.40709E-5 41544 0 NA
7-87757982-T-A p.Asp248Glu missense ADAM22 1 83038 1.20427E-5 41519 0 NA
7-87759700-C-T c.754-3C>T splice_region ADAM22 3 83038 3.6128E-5 41519 1 9.62587E-5
7-87759715-C-T p.Arg256Trp missense ADAM22 15 83060 1.80592E-4 41530 0 5.41781E-4
7-87759723-C-T p.Ser258Ser synonymous ADAM22 1 83094 1.20346E-5 41547 0 2.01062E-5
7-87759724-G-A p.Val259Ile missense ADAM22 3 83086 3.61072E-5 41543 0 8.30179E-6
7-87759729-A-G p.Val260Val synonymous ADAM22 1 83118 1.20311E-5 41559 0 8.03361E-6
7-87759746-C-T p.Ala266Val missense ADAM22 5 83110 6.01612E-5 41555 0 6.36983E-5
7-87759747-G-A p.Ala266Ala synonymous ADAM22 9 83114 1.08285E-4 41557 0 2.23015E-4
7-87759773-TAGTA-T p.Ile276fs frameshift ADAM22 2 83086 2.40714E-5 41543 0 8.30082E-6
7-87760577-A-G c.826-7A>G splice_region ADAM22 3 82732 3.62617E-5 41366 0 3.18613E-5
7-87760584-A-G p.Ile276Val missense+splice_region ADAM22 1 82860 1.20685E-5 41430 0 NA
7-87760609-G-A p.Arg284Lys missense ADAM22 2 83140 2.40558E-5 41570 0 1.60552E-5
7-87760639-C-T p.Ala294Val missense ADAM22 3 83190 3.6062E-5 41595 0 4.98513E-5
7-87760640-G-A p.Ala294Ala synonymous ADAM22 1 83198 1.20195E-5 41599 0 4.01162E-6
7-87760643-T-G p.Thr295Thr synonymous ADAM22 5 83204 6.00933E-5 41602 0 6.25E-4
7-87760649-C-T p.Asn297Asn synonymous ADAM22 2 83202 2.40379E-5 41601 0 3.18634E-5
7-87760657-C-A p.Ala300Asp missense ADAM22 1 83202 1.20189E-5 41601 0 NA
7-87760674-T-C p.Leu306Leu synonymous ADAM22 1 83182 1.20218E-5 41591 0 8.29931E-6
7-87760685-A-G p.Leu309Leu synonymous ADAM22 1 83176 1.20227E-5 41588 0 NA
7-87760686-C-T p.Arg310Cys missense ADAM22 6 83174 7.21379E-5 41587 0 1.20351E-5
7-87760687-G-A p.Arg310His missense ADAM22 1 83178 1.20224E-5 41589 0 5.03525E-4
7-87760687-G-T p.Arg310Leu missense ADAM22 1 83178 1.20224E-5 41589 0 NA
7-87760694-T-C p.Phe312Phe synonymous ADAM22 1 83174 1.2023E-5 41587 0 NA
7-87760705-G-A p.Arg316Lys missense ADAM22 2 83154 2.40518E-5 41577 0 3.18573E-5
7-87760709-G-A p.Arg317Arg synonymous ADAM22 1 83162 1.20247E-5 41581 0 NA
7-87760720-A-G p.Lys321Arg missense ADAM22 1 83138 1.20282E-5 41569 0 6.37024E-5
7-87760725-A-G p.Lys323Glu missense ADAM22 1 83134 1.20288E-5 41567 0 8.02407E-6
7-87760727-A-G p.Lys323Lys synonymous ADAM22 7 83126 8.42095E-5 41563 0 1.66085E-5
7-87760743-C-T p.Leu329Phe missense ADAM22 7 83076 8.42602E-5 41538 0 3.18878E-5
7-87760747-T-C p.Phe330Ser missense ADAM22 2 83084 2.4072E-5 41542 0 NA
7-87760750-C-T p.Ser331Leu missense+splice_region ADAM22 2 83060 2.4079E-5 41530 0 NA
7-87760751-G-A c.992+1G>A splice_donor ADAM22 1 83052 1.20406E-5 41526 0 1.66756E-5
7-87760764-G-C p.Val336Leu missense ADAM22 92 82988 0.00110859 41494 0 0.00254923
7-87760766-A-G p.Val336Val synonymous ADAM22 6 82958 7.23258E-5 41479 0 1.6081E-5
7-87760772-G-A p.Met338Ile missense ADAM22 1 82898 1.2063E-5 41449 0 3.18715E-5
7-87760776-T-C p.Tyr340His missense ADAM22 3 82878 3.61978E-5 41439 0 1.73617E-5
7-87760782-T-C p.Phe342Leu missense ADAM22 3 82830 3.62188E-5 41415 0 4.43774E-5
7-87762190-A-C p.Gln334Pro missense ADAM22 2 83378 2.39871E-5 41689 0 NA
7-87762204-C-T p.Arg339Trp missense ADAM22 12 83390 1.43902E-4 41695 0 3.31384E-5
7-87762205-G-A p.Arg339Gln missense ADAM22 1 83390 1.19918E-5 41695 0 1.65681E-5
7-87762209-C-T p.Ser340Ser synonymous ADAM22 2 83394 2.39825E-5 41697 0 1.20251E-5
7-87762209-C-A p.Ser340Arg missense ADAM22 1 83394 1.19913E-5 41697 0 NA
7-87762210-G-A p.Gly341Arg missense ADAM22 1 83394 1.19913E-5 41697 0 1.65656E-5
7-87762211-G-A p.Gly341Glu missense ADAM22 1 83400 1.19904E-5 41700 0 4.00718E-6
7-87762225-G-T p.Gly346Cys missense ADAM22 1 83402 1.19901E-5 41701 0 2.00333E-5
7-87762240-T-C p.Leu351Leu synonymous ADAM22 1 83408 1.19893E-5 41704 0 2.40365E-5
7-87762242-G-C p.Leu351Phe missense ADAM22 1 83412 1.19887E-5 41706 0 4.00606E-6
7-87762257-C-T p.Gly356Gly synonymous ADAM22 1 83402 1.19901E-5 41701 0 3.18918E-5
7-87762258-G-A p.Val357Met missense ADAM22 1 83404 1.19898E-5 41702 0 3.18552E-5
7-87762262-A-G p.Asn358Ser missense ADAM22 1 83404 1.19898E-5 41702 0 1.20201E-5
7-87763670-T-G p.Val368Val synonymous ADAM22 1 82878 1.20659E-5 41439 0 3.42091E-5
7-87763674-C-G p.Leu370Val missense ADAM22 3 82894 3.61908E-5 41447 1 NA
7-87763685-A-T p.Ser373Ser synonymous ADAM22 2 82952 2.41103E-5 41476 0 8.51325E-6
7-87763691-C-T p.Ala375Ala synonymous ADAM22 1 82970 1.20525E-5 41485 0 4.06312E-6
7-87763708-T-C p.Ile381Thr missense ADAM22 1 82984 1.20505E-5 41492 0 NA
7-87763721-A-G p.Arg385Arg synonymous ADAM22 5 82990 6.02482E-5 41495 0 3.18552E-5
7-87763728-G-T p.Ala388Ser missense ADAM22 1 82972 1.20523E-5 41486 0 4.07528E-6
7-87765308-C-T p.Cys394Cys synonymous ADAM22 2 83302 2.4009E-5 41651 0 8.06595E-6
7-87765312-G-A p.Asp396Asn missense ADAM22 2 83296 2.40108E-5 41648 0 3.18431E-5
7-87765316-C-T p.Thr397Met missense ADAM22 1 83308 1.20036E-5 41654 0 3.3168E-5
7-87765319-G-T p.Trp398Leu missense ADAM22 3 83314 3.60084E-5 41657 0 3.18492E-5
7-87765323-C-T p.Ser399Ser synonymous ADAM22 11 83298 1.32056E-4 41649 0 2.23866E-4
7-87765324-G-A p.Gly400Arg missense ADAM22 1 83300 1.20048E-5 41650 0 8.05795E-6
7-87765330-A-G p.Ile402Val missense ADAM22 2 83316 2.4005E-5 41658 0 3.1841E-5
7-87772337-A-G c.1221-4A>G splice_region ADAM22 2 82772 2.41628E-5 41386 0 8.30634E-6
7-87772368-G-A p.Gln416Gln synonymous ADAM22 6 83058 7.22387E-5 41529 0 4.41884E-5
7-87772387-C-G p.His423Asp missense ADAM22 1 83118 1.20311E-5 41559 0 NA
7-87772403-G-T p.Ser428Ile missense ADAM22 1 83118 1.20311E-5 41559 0 9.5584E-5
7-87772409-G-T p.Gly430Val missense ADAM22 1 83100 1.20337E-5 41550 0 NA
7-87772409-G-A p.Gly430Asp missense ADAM22 1 83100 1.20337E-5 41550 0 NA
7-87772415-C-T p.Ala432Val missense ADAM22 1 83094 1.20346E-5 41547 0 8.28871E-6
7-87772420-C-T p.Leu434Phe missense ADAM22 2 83086 2.40714E-5 41543 0 NA
7-87772426-A-C p.Asn436His missense ADAM22 1 83076 1.20372E-5 41538 0 NA
7-87774433-C-T c.1321-7C>T splice_region ADAM22 1 83288 1.20065E-5 41644 0 3.32353E-5
7-87774460-T-C p.Cys447Cys synonymous ADAM22 2 83344 2.39969E-5 41672 0 1.60412E-5
7-87774474-T-C p.Ile452Thr missense ADAM22 12 83342 1.43985E-4 41671 0 5.03525E-4
7-87774505-C-T p.Thr462Thr synonymous ADAM22 1 83346 1.19982E-5 41673 0 NA
7-87774507-C-T p.Pro463Leu missense ADAM22 3 83338 3.5998E-5 41669 0 6.25E-4
7-87774508-G-A p.Pro463Pro synonymous ADAM22 6 83344 7.19908E-5 41672 0 1.66589E-5
7-87774723-T-G c.1393-7T>G splice_region ADAM22 197 82774 0.00237997 41387 1 0.00512968
7-87774727-T-C c.1393-3T>C splice_region ADAM22 7055 82644 0.0853662 41322 373 0.1225
7-87774790-T-A p.Cys485Ser missense ADAM22 1 82818 1.20747E-5 41409 0 4.01594E-6
7-87774798-C-T p.Asp487Asp synonymous ADAM22 46 82744 5.55932E-4 41372 0 0.00100806
7-87774801-T-C p.Gly488Gly synonymous ADAM22 4 82700 4.83676E-5 41350 0 1.67157E-5
7-87774801-T-A p.Gly488Gly synonymous ADAM22 1 82700 1.20919E-5 41350 0 NA
7-87778284-C-T c.1486-8C>T splice_region ADAM22 3 82288 3.64573E-5 41144 0 4.8151E-4
7-87778295-C-T p.Gln497* stop_gained ADAM22 1 82520 1.21183E-5 41260 0 4.06124E-6
7-87778297-G-C p.Gln497His missense ADAM22 1 82552 1.21136E-5 41276 0 8.9865E-6
7-87778298-C-G p.Pro498Ala missense ADAM22 1 82564 1.21118E-5 41282 0 4.04093E-6
7-87778306-C-T p.Gly500Gly synonymous ADAM22 1 82642 1.21004E-5 41321 0 NA
7-87778310-G-A p.Val502Met missense ADAM22 1 82698 1.20922E-5 41349 0 NA
7-87778312-G-A p.Val502Val synonymous ADAM22 4 82712 4.83606E-5 41356 0 3.18715E-5
7-87778315-C-T p.Cys503Cys synonymous ADAM22 10 82714 1.20899E-4 41357 0 9.56694E-5
7-87778333-T-G p.Asp509Glu missense ADAM22 10 82824 1.20738E-4 41412 0 1.45753E-4
7-87778337-G-C p.Asp511His missense ADAM22 2 82834 2.41447E-5 41417 0 NA
7-87778343-C-A p.Arg513Ser missense ADAM22 10 82826 1.20735E-4 41413 0 5.15482E-5
7-87778344-G-A p.Arg513His missense ADAM22 1 82848 1.20703E-5 41424 0 4.02525E-6
7-87778350-C-T p.Thr515Met missense ADAM22 1 82838 1.20718E-5 41419 0 1.20766E-5
7-87778355-T-C p.Ser517Pro missense ADAM22 1 82838 1.20718E-5 41419 0 NA
7-87778380-A-T c.1566+8A>T splice_region ADAM22 55 82656 6.65408E-4 41328 4 0.00317462
7-87780289-T-C c.1567-7T>C splice_region ADAM22 4 83104 4.81325E-5 41552 0 NA
7-87780292-C-T c.1567-4C>T splice_region ADAM22 15 83116 1.80471E-4 41558 0 7.70837E-4
7-87780301-C-T p.Ala524Ala synonymous ADAM22 19 83140 2.2853E-4 41570 0 1.91205E-4
7-87780302-C-A p.Pro525Thr missense ADAM22 15 83152 1.80393E-4 41576 0 6.37308E-4
7-87780346-G-A p.Gln539Gln splice_region+synonymous ADAM22 230 83180 0.00276509 41590 1 0.00477677
7-87780350-G-A c.1617+4G>A splice_region ADAM22 1 83200 1.20192E-5 41600 0 9.55657E-5
7-87780564-C-T c.1618-8C>T splice_region ADAM22 2 82920 2.41196E-5 41460 0 1.90947E-4
7-87780565-G-A c.1618-7G>A splice_region ADAM22 147 82936 0.00177245 41468 0 0.00200726
7-87780567-T-C c.1618-5T>C splice_region ADAM22 45 82950 5.42495E-4 41475 0 7.95976E-4
7-87780569-T-C c.1618-3T>C splice_region ADAM22 12 82986 1.44603E-4 41493 0 1.12362E-4
7-87780625-T-C p.Ile557Ile synonymous ADAM22 1 83158 1.20253E-5 41579 0 4.01081E-6
7-87782529-G-A c.1682-7G>A splice_region ADAM22 1 82766 1.20823E-5 41383 0 1.91832E-5
7-87782529-GC-CT c.1682-7_1682-6delGCinsCT splice_region ADAM22 2 82766 2.41645E-5 41383 0 NA
7-87782532-T-G c.1682-4T>G splice_region ADAM22 5 82818 6.03733E-5 41409 0 8.12473E-6
7-87782546-A-G p.Ala564Ala synonymous ADAM22 2 82958 2.41086E-5 41479 0 8.06679E-6
7-87782567-G-A p.Glu571Glu synonymous ADAM22 1 83044 1.20418E-5 41522 0 6.37024E-5
7-87782571-C-T p.Leu573Leu synonymous ADAM22 1 83064 1.20389E-5 41532 0 4.02395E-6
7-87782581-A-G p.Glu576Gly missense ADAM22 1 83090 1.20351E-5 41545 0 NA
7-87782588-G-A p.Thr578Thr synonymous ADAM22 6 83080 7.22195E-5 41540 0 NA
7-87782597-T-C p.Gly581Gly synonymous ADAM22 1 83054 1.20404E-5 41527 0 1.69101E-4
7-87782611-A-G p.Asp586Gly missense ADAM22 2 83088 2.40709E-5 41544 0 NA
7-87782612-C-T p.Asp586Asp synonymous ADAM22 1 83084 1.2036E-5 41542 0 NA
7-87782640-C-T p.Arg596Trp missense+splice_region ADAM22 13 82970 1.56683E-4 41485 0 1.15603E-4
7-87782644-G-A c.1787+3G>A splice_region ADAM22 1 82912 1.2061E-5 41456 0 8.99087E-6
7-87782647-G-A c.1787+6G>A splice_region ADAM22 3 82886 3.61943E-5 41443 0 NA
7-87785208-G-A p.Val598Val synonymous ADAM22 1 83084 1.2036E-5 41542 0 8.30289E-6
7-87785235-T-C p.Asn607Asn synonymous ADAM22 262 83102 0.00315275 41551 4 0.0075
7-87785240-G-A p.Gly609Asp missense ADAM22 1 83094 1.20346E-5 41547 0 2.48789E-5
7-87785241-C-T p.Gly609Gly synonymous ADAM22 246 83090 0.00296065 41545 5 0.00805804
7-87785252-G-C p.Arg613Thr missense ADAM22 1 83114 1.20317E-5 41557 0 NA
7-87785265-C-T p.Leu617Leu synonymous ADAM22 29 83080 3.49061E-4 41540 0 5.73468E-4
7-87785266-G-A p.Asp618Asn missense ADAM22 1 83078 1.20369E-5 41539 0 3.31708E-5
7-87785277-C-T p.Ile621Ile synonymous ADAM22 1 83060 1.20395E-5 41530 0 3.18492E-5
7-87785279-C-T p.Thr622Ile missense ADAM22 1 83050 1.20409E-5 41525 0 2.65406E-4
7-87785288-T-C p.Leu625Ser missense ADAM22 1 83030 1.20438E-5 41515 0 NA
7-87785303-G-A p.Gly630Glu missense ADAM22 10 82992 1.20494E-4 41496 0 2.22944E-4
7-87785309-C-G p.Thr632Arg missense ADAM22 1 82966 1.20531E-5 41483 0 NA
7-87785309-C-T p.Thr632Ile missense ADAM22 1 82966 1.20531E-5 41483 0 NA
7-87785316-C-A p.Asn634Lys missense ADAM22 2 82942 2.41132E-5 41471 0 8.31103E-6
7-87785327-TATCTAACC-T c.1907+7_1907+14delATCTAACC splice_region ADAM22 3 82910 3.61838E-5 41455 0 8.32431E-6
7-87792334-C-A p.His639Asn missense ADAM22 2 83144 2.40547E-5 41572 0 3.18512E-5
7-87792348-A-G p.Glu643Glu synonymous ADAM22 1 83162 1.20247E-5 41581 0 6.5163E-5
7-87792353-A-T p.Asp645Val missense ADAM22 49 83150 5.89296E-4 41575 0 0.00166294
7-87792353-A-C p.Asp645Ala missense ADAM22 1 83150 1.20265E-5 41575 0 NA
7-87792366-C-G p.Gly649Gly synonymous ADAM22 2 83144 2.40547E-5 41572 0 3.19816E-5
7-87792381-G-A p.Gly654Gly synonymous ADAM22 1 83094 1.20346E-5 41547 0 3.19264E-5
7-87792387-T-C p.Pro656Pro synonymous ADAM22 1 83080 1.20366E-5 41540 0 4.03717E-6
7-87792414-A-G p.Glu665Glu synonymous ADAM22 1 83068 1.20383E-5 41534 0 NA
7-87792418-A-G p.Arg667Gly missense ADAM22 1 83044 1.20418E-5 41522 0 NA
7-87792430-G-A p.Val671Met missense ADAM22 1 83034 1.20433E-5 41517 0 NA
7-87792435-T-G p.Ala672Ala synonymous ADAM22 1 83046 1.20415E-5 41523 0 NA
7-87792445-T-A p.Phe676Ile missense ADAM22 1 83036 1.2043E-5 41518 0 3.18593E-5
7-87792448-A-G p.Ser677Gly missense ADAM22 1 83026 1.20444E-5 41513 0 3.18552E-5
7-87792463-A-G p.Ser682Gly missense ADAM22 1 83000 1.20482E-5 41500 0 NA
7-87792465-T-C p.Ser682Ser synonymous ADAM22 1 82994 1.20491E-5 41497 0 NA
7-87792466-A-AGCAT p.Lys683fs frameshift ADAM22 1 82990 1.20496E-5 41495 0 NA
7-87792467-A-G p.Lys683Arg missense ADAM22 2 82998 2.4097E-5 41499 0 NA
7-87792479-T-C p.Ile687Thr missense ADAM22 2 82970 2.41051E-5 41485 0 1.2475E-5
7-87792483-C-T p.Cys688Cys synonymous ADAM22 3 82966 3.61594E-5 41483 0 6.37227E-5
7-87792492-T-G p.Asn691Lys missense ADAM22 1 82936 1.20575E-5 41468 0 NA
7-87792502-A-T c.2076+7A>T splice_region ADAM22 1 82858 1.20688E-5 41429 0 8.92156E-6
7-87795139-G-A c.2077-8G>A splice_region ADAM22 2 82802 2.4154E-5 41401 0 6.37755E-5
7-87795152-C-T p.Cys694Cys synonymous ADAM22 1 82942 1.20566E-5 41471 0 NA
7-87795166-A-AGT p.Asn703fs frameshift ADAM22 1 82984 1.20505E-5 41492 0 NA
7-87795167-G-A p.Lys699Lys synonymous ADAM22 10 82994 1.20491E-4 41497 0 2.55037E-4
7-87795206-C-T p.Asn712Asn synonymous ADAM22 1 82958 1.20543E-5 41479 0 3.18552E-5
7-87795207-A-T p.Thr713Ser missense ADAM22 7 82952 8.43861E-5 41476 0 1.08124E-4
7-87795223-A-G p.Asn718Ser missense ADAM22 26 82948 3.13449E-4 41474 1 3.26969E-4
7-87795237-A-G p.Thr723Ala missense ADAM22 9 82920 1.08538E-4 41460 0 9.55657E-5
7-87795239-T-C p.Thr723Thr synonymous ADAM22 1 82914 1.20607E-5 41457 0 8.33875E-6
7-87795254-T-C p.Ser728Ser synonymous ADAM22 1 82848 1.20703E-5 41424 0 NA
7-87795257-C-A p.Gly729Gly synonymous ADAM22 2 82842 2.41423E-5 41421 0 NA
7-87795267-T-C c.2191+6T>C splice_region ADAM22 1 82798 1.20776E-5 41399 0 NA
7-87795269-C-G c.2191+8C>G splice_region ADAM22 1 82794 1.20782E-5 41397 0 NA
7-87797465-C-T p.Thr735Thr synonymous ADAM22 2 82754 2.4168E-5 41377 0 3.18552E-5
7-87797493-AC-CT p.Thr745Leu missense ADAM22 2 82898 2.4126E-5 41449 0 NA
7-87797509-C-T p.Ala750Val missense ADAM22 4 82868 4.82695E-5 41434 0 1.20528E-5
7-87797513-CATATT-C p.Ile752fs frameshift ADAM22 2 82874 2.4133E-5 41437 0 8.35897E-6
7-87797531-G-A p.Ala757Ala synonymous ADAM22 11 82846 1.32776E-4 41423 0 9.23578E-5
7-87797540-T-C p.Tyr760Tyr splice_region+synonymous ADAM22 4 82802 4.8308E-5 41401 0 5.04032E-4
7-87800853-GA-G c.2283-5delA splice_region ADAM22 1 80996 1.23463E-5 40498 0 4.3704E-6
7-87800867-G-A p.Arg764Gln missense ADAM22 2 80928 2.47133E-5 40464 0 4.17865E-5
7-87808273-TA-T p.Lys777fs frameshift ADAM22 1 83264 1.201E-5 41632 0 NA
7-87808280-G-A p.Lys777Lys synonymous ADAM22 2 83276 2.40165E-5 41638 0 NA
7-87808307-C-A p.Ser786Arg missense ADAM22 1 83258 1.20109E-5 41629 0 NA
7-87808309-A-T p.Asp787Val missense ADAM22 1 83264 1.201E-5 41632 0 4.0041E-6
7-87808317-C-T p.Pro790Ser missense ADAM22 1 83268 1.20094E-5 41634 0 NA
7-87808319-C-T p.Pro790Pro synonymous ADAM22 3 83260 3.60317E-5 41630 0 3.18634E-5
7-87808334-C-T p.Asn795Asn synonymous ADAM22 1 83242 1.20132E-5 41621 0 8.31172E-6
7-87808370-G-C p.Leu106Leu synonymous ADAM22 1 83064 1.20389E-5 41532 0 NA
7-87808372-C-A p.Ser107* stop_gained ADAM22 1 83048 1.20412E-5 41524 0 NA
7-87808398-A-G p.Ile116Val missense ADAM22 1 82822 1.20741E-5 41411 0 NA
7-87808405-A-G p.His118Arg missense ADAM22 2 82792 2.41569E-5 41396 0 4.15313E-6
7-87808441-G-GGAAAAAAGA p.Ser130delinsArgLysLysAsp disruptive_inframe_insertion ADAM22 1 81854 1.22169E-5 40927 0 NA
7-87810796-A-G c.2283-6A>G splice_region ADAM22 1 82674 1.20957E-5 41337 0 NA
7-87810797-T-C c.2283-5T>C splice_region ADAM22 1 82720 1.2089E-5 41360 0 NA
7-87810838-T-C p.His809His synonymous ADAM22 1 82900 1.20627E-5 41450 0 NA
7-87810857-C-G p.Pro816Ala missense ADAM22 2 82876 2.41324E-5 41438 0 NA
7-87810862-C-G p.Asp817Glu missense ADAM22 1 82876 1.20662E-5 41438 0 NA
7-87810863-A-G p.Thr818Ala missense ADAM22 1 82860 1.20685E-5 41430 0 NA
7-87810871-T-TCCA p.His820_Ile821insPro conservative_inframe_insertion ADAM22 1 82836 1.2072E-5 41418 0 NA
7-87810871-T-C p.His820His synonymous ADAM22 2 82836 2.41441E-5 41418 0 1.66105E-5
7-87810903-G-A p.Arg831Gln missense ADAM22 3 82690 3.62801E-5 41345 0 NA
7-87811295-G-C p.Lys844Asn missense ADAM22 2 82878 2.41319E-5 41439 0 NA
7-87811323-C-G p.Arg854Gly missense ADAM22 1 82570 1.21109E-5 41285 0 NA
7-87811427-G-T c.*84G>T splice_region ADAM22 1 78202 1.27874E-5 39101 0 NA
7-87813606-G-T c.651-1G>T splice_acceptor ADAM22 1 51920 1.92604E-5 25960 0 NA
7-87813619-A-G p.Gln221Gln synonymous ADAM22 4 52018 7.68965E-5 26009 0 8.22504E-5
7-87813623-C-T p.Pro223Ser missense ADAM22 1 52290 1.91241E-5 26145 0 2.64961E-5
7-87813635-C-T p.His227Tyr missense ADAM22 6050 52200 0.1159 26100 476 0.208113
7-87813644-G-A p.Ala230Thr missense ADAM22 2 52586 3.80329E-5 26293 0 1.46649E-4
7-87813649-G-A p.Gln231Gln synonymous ADAM22 1 52684 1.89811E-5 26342 0 7.3078E-5
7-87813656-C-G p.Pro234Ala missense ADAM22 1 52714 1.89703E-5 26357 0 NA
7-87813675-CA-C p.Gly242fs frameshift ADAM22 2 52660 3.79795E-5 26330 0 6.43863E-5
7-87813681-GCT-G p.Ser243fs frameshift ADAM22 1 52520 1.90404E-5 26260 0 NA
7-87813681-G-T p.Gly242Val missense ADAM22 3 52520 5.71211E-5 26260 0 2.59211E-5
7-87813687-A-T p.Asp244Val missense ADAM22 1 52524 1.90389E-5 26262 0 NA
7-87813688-CAGCCCCCAG-C p.Ser245_Gln247del disruptive_inframe_deletion ADAM22 1 52512 1.90433E-5 26256 0 NA
7-87813693-C-G p.Pro246Arg missense ADAM22 2 52446 3.81345E-5 26223 0 NA
7-87815929-G-C c.2469-1G>C splice_acceptor ADAM22 1 82758 1.20834E-5 41379 0 4.01735E-6
7-87815933-T-C p.Tyr824Tyr synonymous ADAM22 9 82834 1.08651E-4 41417 0 4.96952E-5
7-87815940-C-A p.Pro827Thr missense ADAM22 3 82954 3.61646E-5 41477 0 6.36983E-5
7-87815942-A-G p.Pro827Pro synonymous ADAM22 1 82986 1.20502E-5 41493 0 6.62603E-5
7-87815949-A-C p.Lys830Gln missense ADAM22 1 83040 1.20424E-5 41520 0 NA
7-87815976-G-T p.Val839Leu missense ADAM22 1 83044 1.20418E-5 41522 0 8.02085E-6
7-87815976-G-C p.Val839Leu missense ADAM22 1 83044 1.20418E-5 41522 0 NA
7-87816004-G-A p.Gly848Glu missense ADAM22 26 82858 3.1379E-4 41429 0 0.00100806
7-87816024-A-G c.2555+8A>G splice_region ADAM22 1 81944 1.22035E-5 40972 0 1.62026E-5
7-87822424-A-C c.2577-7A>C splice_region ADAM22 3 83174 3.6069E-5 41587 0 NA
7-87822440-T-A p.Ser862Ser synonymous ADAM22 2 83250 2.4024E-5 41625 0 4.00859E-6
7-87822446-CAA-C p.Lys865fs frameshift ADAM22 1 83260 1.20106E-5 41630 0 NA
7-87822459-T-A p.Ser869Thr missense ADAM22 1 83270 1.20091E-5 41635 0 1.6567E-5
7-87822470-G-A p.Gly872Gly synonymous ADAM22 5 83288 6.00327E-5 41644 0 NA
7-87822510-C-T p.Pro886Ser missense ADAM22 1 83304 1.20042E-5 41652 0 3.1841E-5
7-87822513-C-T p.Leu887Phe missense ADAM22 1 83306 1.20039E-5 41653 0 NA
7-87822530-G-C p.Lys892Asn missense ADAM22 1 83308 1.20036E-5 41654 0 1.66639E-5
7-87822534-G-A p.Val894Met missense ADAM22 88 83306 0.00105635 41653 0 0.00302115
7-87822534-G-C p.Val894Leu missense ADAM22 2 83306 2.40079E-5 41653 0 NA
7-87822541-G-A p.Arg896Gln missense ADAM22 15 83284 1.80107E-4 41642 0 0.00100705
7-87822562-G-A c.2700+8G>A splice_region ADAM22 1 83242 1.20132E-5 41621 0 NA
7-87825801-A-G p.Ile906Val missense ADAM22 1 83184 1.20215E-5 41592 0 NA